31 research outputs found
Isotopic and spin selectivity of H_2 adsorbed in bundles of carbon nanotubes
Due to its large surface area and strongly attractive potential, a bundle of
carbon nanotubes is an ideal substrate material for gas storage. In addition,
adsorption in nanotubes can be exploited in order to separate the components of
a mixture. In this paper, we investigate the preferential adsorption of D_2
versus H_2(isotope selectivity) and of ortho versus para(spin selectivity)
molecules confined in the one-dimensional grooves and interstitial channels of
carbon nanotube bundles. We perform selectivity calculations in the low
coverage regime, neglecting interactions between adsorbate molecules. We find
substantial spin selectivity for a range of temperatures up to 100 K, and even
greater isotope selectivity for an extended range of temperatures,up to 300 K.
This isotope selectivity is consistent with recent experimental data, which
exhibit a large difference between the isosteric heats of D_2 and H_2 adsorbed
in these bundles.Comment: Paper submitted to Phys.Rev. B; 17 pages, 2 tables, 6 figure
Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial
Background: Priming COVID-19 vaccine schedules have been deployed at variable intervals globally, which might influence immune persistence and the relative importance of third-dose booster programmes. Here, we report exploratory analyses from the Com-COV trial, assessing the effect of 4-week versus 12-week priming intervals on reactogenicity and the persistence of immune response up to 6 months after homologous and heterologous priming schedules using the vaccines BNT162b2 (tozinameran, Pfizer/BioNTech) and ChAdOx1 nCoV-19 (AstraZeneca).
Methods: Com-COV was a participant-masked, randomised immunogenicity trial. For these exploratory analyses, we used the trial's general cohort, in which adults aged 50 years or older were randomly assigned to four homologous and four heterologous vaccine schedules using BNT162b2 and ChAdOx1 nCoV-19 with 4-week or 12-week priming intervals (eight groups in total). Immunogenicity analyses were done on the intention-to-treat (ITT) population, comprising participants with no evidence of SARS-CoV-2 infection at baseline or for the trial duration, to assess the effect of priming interval on humoral and cellular immune response 28 days and 6 months post-second dose, in addition to the effects on reactogenicity and safety. The Com-COV trial is registered with the ISRCTN registry, 69254139 (EudraCT 2020–005085–33).
Findings: Between Feb 11 and 26, 2021, 730 participants were randomly assigned in the general cohort, with 77–89 per group in the ITT analysis. At 28 days and 6 months post-second dose, the geometric mean concentration of anti-SARS-CoV-2 spike IgG was significantly higher in the 12-week interval groups than in the 4-week groups for homologous schedules. In heterologous schedule groups, we observed a significant difference between intervals only for the BNT162b2–ChAdOx1 nCoV-19 group at 28 days. Pseudotyped virus neutralisation titres were significantly higher in all 12-week interval groups versus 4-week groups, 28 days post-second dose, with geometric mean ratios of 1·4 (95% CI 1·1–1·8) for homologous BNT162b2, 1·5 (1·2–1·9) for ChAdOx1 nCoV-19–BNT162b2, 1·6 (1·3–2·1) for BNT162b2–ChAdOx1 nCoV-19, and 2·4 (1·7–3·2) for homologous ChAdOx1 nCoV-19. At 6 months post-second dose, anti-spike IgG geometric mean concentrations fell to 0·17–0·24 of the 28-day post-second dose value across all eight study groups, with only homologous BNT162b2 showing a slightly slower decay for the 12-week versus 4-week interval in the adjusted analysis. The rank order of schedules by humoral response was unaffected by interval, with homologous BNT162b2 remaining the most immunogenic by antibody response. T-cell responses were reduced in all 12-week priming intervals compared with their 4-week counterparts. 12-week schedules for homologous BNT162b2 and ChAdOx1 nCoV-19–BNT162b2 were up to 80% less reactogenic than 4-week schedules.
Interpretation: These data support flexibility in priming interval in all studied COVID-19 vaccine schedules. Longer priming intervals might result in lower reactogenicity in schedules with BNT162b2 as a second dose and higher humoral immunogenicity in homologous schedules, but overall lower T-cell responses across all schedules. Future vaccines using these novel platforms might benefit from schedules with long intervals.
Funding: UK Vaccine Taskforce and National Institute for Health and Care Research
Weak probe readout of coherent impurity orbital superpositions in silicon
Contains fulltext :
166167.pdf (publisher's version ) (Open Access
Sideband phases and laser excitation
SIGLEAvailable from British Library Document Supply Centre- DSC:9091.9F(AERE-M--3553) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Low energy charge capture cross sections
SIGLEAvailable from British Library Lending Division - LD:9091.9F(AERE-R--11281) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Rydberg atoms
HMSO 3.00SIGLELD:9091.9F(AERE-R--9986). / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Charge transfer data for fusion plasmas
6.00SIGLEAvailable from British Library Document Supply Centre- DSC:9091.9F(AERE-R--12631) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
The role of molecular hydrogen in plasma recombination
We consider the effect of the presence of molecular hydrogen on plasma recombination at temperatures of a few electron volts. The role of 2-body processes such as ion conversion and dissociative attachment in accelerating the recombination is exposed, both in a simplified model, which can be solved analytically, and in more realistic numerical calculations. All the important atomic and molecular processes are included in a set of non-linear rate equations, from which we identify the important parameters of the model and thereby show which cross sections are critical. Although we do not include transport explicitly we are able to extend the model to mimic recycling at the plasma edge. This enables us to demonstrate the importance of the contribution of H_2 to recombination. Our model is primitive, but it enables us to identify processes which are important in modelling H_2-plasma interactions, and which will therefore have to be treated in more complex plasma codes. We find that some of the ideas basic to atomic modelling of plasmas may have to be revised if molecular processes are important in the plasma dynamics. In particular, the non-linearities we discuss lead to instabilities, which allow the co-existence of several solutions for the same physical parameters. (orig.)8 refs.Available from TIB Hannover: RA 831(3258) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Final report on JET Contract No. JT7/10880 between JET joint undertaking and Harwell Laboratory on Be-H charge transfer in the JET boundary
SIGLEAvailable from British Library Document Supply Centre- DSC:9091.9F(AERE-R--13136) / BLDSC - British Library Document Supply CentreGBUnited Kingdo